Haemoglobin Synthesis
Saturday 7 October 2017
Haemoglobin Synthesis
If you are not willing to learn, no one can help you. If you are determined to learn, no one can stop you- Zig Ziglar
Hello fellas ! Let's learn something new today. I guess you all already knew what i am going to tell you guys... Yeahhh, you read the headline already, but i bet you guys do not know what is the content isn't? I knew its going to be so bored(*cries) but well the world belongs to those who reading. Grab all the knowledge because knowledge is the life of mind. Happy reading and do drop your comments below for any question regarding the topic 😉
So, here we go. Haemoglobin synthesis or in other word how haemoglobin is being made?
Actually, 65% of haemoglobin is produced in the erythroblast and 35% at the reticulocytes stage. Both erythroblast and the reticulocytes is an unmature form of our red blood cell. As i said in the previous post, the hemoglobin composed of globin part and also the haem part. The haem part is synthesis mostly in the mitochondria while the globin part is synthesis in the polyribosomes.
So, let's explore the world of haemoglobin~
Shall we start with the production of HAEM?
- First of all, the synthesis of haemoglobin required an iron. The iron that had been stored in the storage site such as liver will be transported out to the eryhtroblast by the transferrin-transferrin is a transporter protein that carry the iron.
- Then, the transferrin will enter the eryhtroblast and released the iron into the cytosol of the cell.
- The free transferrin will be secreted out to transport another iron and the recycle rotate.
- When the amount of iron in the erythroblast is high, the iron will be stored in the ferritin, while when the amount of iron in the cell is decrease, ferritin will released the iron into the cytoplasm-ferritin is a temporary storage for iron.
- The iron then will enter the mitochondria.
- In mitochondria, glycine ans the succinyl coenzyme A will undergo condensation process with the help of vitamin B₆ as the coenzyme forming δ-ALA.
- In cytoplasm, the δ-ALA will be condensed to form uroporphyrinogen that then will undergo condensation forming coproporphyrinogen.
- The coproporphyrinogen then reenter the mitochondria and change to the protoporphyrin.
- This protoporphyrin will bind with the iron producing the 4 molecules of HAEM.
Let's continue with the production of GLOBIN.
- First, the free amino acid in the erythroblast will be translated by the ribosomes forming 𝛂 and 𝛃 chain that then will form 𝛂₂𝛃₂ globin.
- These 𝛂₂𝛃₂ globin will bind with haem molecules producing HAEMOGLOBIN. Finally...!! yeayhhhhhh.
But, honestly guys, i don't think that you understand what i am babbling about. Bahahaha how sad do i sound(*cries). So, I attach the image related to haemoglobin synthesis to help you to have a better understanding.
I really thank God for this really complicated process yet perfectly create that absolutely beyond our imagination and limitation. Without this haemoglobin in our red blood cells, i can't imagine how disaster it will be. So, let's thankful for this blessing fellas !
If you finish your reading till here, i would say congratulation buddies !!! Hope you enjoy the reading(hope so...maybe) and gain some knowledge from it. Once again, do drop your comments about this entry or maybe some kind of question(if you have one) due to this topic.
See you soon peeps. Blessed.
1 comments
bmedicalscience2020 said...Ma shaa allah. Allah creations is so perfect. Cant wait to know more about all this amazing creations of Allah